Researching Interest
1. Molecular Recognition of Synthetic Receptors
1.1 Ionic Recognition of Crown Ethers
Syntheses of heterocyclic crown ethers, lariat crown ethers, benzocrown ethers, bis(crown ether)s and their recognition behavior towards cationic and anionic guests.
1.2 Molecular and Ionic Recognition of Calixarenes
Syntheses of modified calix[4]arenes, calix[6]arenas, calix[8]arenas, biscalixarenes and their recognition behaviors towards ionic and molecular guests such as dyes, amino acids and drug molecules.
1.3 Molecular Recognition of Cyclodextrins
Syntheses of modified cyclodextrins bearing chromophoric or aliphatic substituents and their recognition behaviors towards organic and biological guests.
1.4 Cooperative multiple recognition in supramolecular systems
Syntheses of bis(cyclodextrin)s, cyclodextrin-calixarene conjugates, cyclodextrin-crown ether conjugates, metallooligocyclodextrins and their "multi-site, multi-mode" recognition behaviors towards organic and biological guests such as dyes, peptides, steroids, and drug molecules.
2. Molecular Assembly of Synthetic Receptors and Construction of Nano-sized Supramolecular Aggregates
Self-assembly of synthetic receptors through noncovalent interactions such as hydrogen-bond, p-p stacking, van der Waals and hydrophobic interactions; Guest-induced aggregation of synthetic receptors mediated by metal coordination or inclusion complexation; Molecular assembly of cyclodextrins on the surface of gold; Polyrotaxenes and polypseudorotaxenes; Morphology of nano-sized supramolecular aggregates; Material and biological functions
of supramolecular aggregates.
3. Application of Supramolecular Technology in Molecular Pharmaceutics
Recognition mechanism of synthetic receptors towards drug molecules; Design of cyclodextrin-functioned combination drug; Enzyme mimics of synthetic receptors.
4. Thermodynamics of Molecular Recognition and Assembly
Microcalorimetric studies of host-guest complexation; Thermodynamic origin of molecular assembly; Thermoanalyses of supramolecular aggregates.
 

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